Trental (Oxpentifylline Tablets)

Trental (Oxpentifylline Tablets) used 

Trental (Oxpentifylline Tablets) are used to treat a variety of conditions caused by poor circulation, including peripheral artery disease (also known as peripheral occlusive vascular disease), which is when the large arteries in the arms and legs become obstructed or partially blocked. This blockage is usually due to atherosclerosis (cholesterol deposition in the artery wall), inflammatory processes, thrombus formation (blood clot) in the artery wall, or an embolism (a blockage caused by a blood clot that has travelled from another location). Arterial obstruction can cause ulcers or even gangrene and can be a symptom of diabetes. Decreased blood flow in the affected limb can also cause pain, weakness, numbness, or muscle cramps (claudication).Trental (Oxpentifylline Tablets) are also used to treat circulatory disorders in the eyes and ears, where the blood vessels have degenerated and can lead to impairment of sight and hearing. Trental (Oxpentifylline Tablets) Increases the blood supply which helps relieve symptoms of peripheral occlusive vascular disease.

Trental (Oxpentifylline Tablets) work

Trental (Oxpentifylline Tablets) contain oxpentifylline, a methylated xanthine derivative that acts as a competitive nonselective inhibitor of phosphodiesterase, an enzyme that regulates the production of chemicals used as intracellular messengers; it is also a nonselective adenosine receptor antagonist, which blocks the action of adenosine, a chemical that has a regulatory function at the cellular level in processes like inflammation. Oxpentifylline in Trental (Oxpentifylline Tablets) has several actions, including direct effects on the blood vessel wall by blocking the adenosine receptor and causing blood vessels to relax and widen (vasodilation). This help improve blood circulation in people with peripheral arterial disease by increasing blood flow through the smaller vessels and thereby allowing more oxygen to get to peripheral tissues in the extremities such as in the hands and feet. Inhibition of phosphodiesterase can prevent the formation of chemicals like leukotrienes and TNF-alpha that promote inflammation and can cause blood to clot more easily and blood vessels to constrict or narrow (vasoconstriction). This action of oxpentifylline in Trental (Oxpentifylline Tablets) thereby decreases the risk of thrombus formation (blood clot that forms by platelet aggregation). It is also thought that oxpentifylline in Trental (Oxpentifylline Tablets) increases red blood cell deformability which helps them pass more easily through constricted blood vessels, thereby decreasing the viscosity of blood, which is a measure of resistance to blood flow through the blood vessels. Another possible action of oxpentifylline in Trental (Oxpentifylline Tablets) is lowering the concentration of blood fibrinogen, a blood protein that activates the clotting process. The combined actions of Trental (Oxpentifylline Tablets) promote blood flow through peripheral blood vessels and oxygen delivery to the tissues, which helps reduce the pain and tissue damage associated with peripheral artery disease.